Best Medicine Soundtrack Season 2 (2026) Guide
Following the dramatic cliffhangers of the first season, Season 2 of FOX's medical dramedy Best Medicine brings Dr. Martin Best (Josh Charles) back to the quirky coastal town of Port Wenn, Maine, where his medical brilliance continues to clash with his abrasive bedside manner and secret blood phobia. Relationships are put to the test as Martin reluctantly navigates a complicated love triangle involving local schoolteacher Louisa Gavin (Abigail Spencer) and the unexpected arrival of his ex-partner. Forced to confront deeper emotional walls and his intense fear of intimacy, Martin must balance solving the town's wildest new medical mysteries alongside an eccentric supporting cast, proving that adapting to small-town life is a challenge he still hasn't quite cured.
Episode 1: Be Careful What You Fish For (Sep 22, 2026)
While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.
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Cecilia
Three Mile Hill
Scene Context: Search parties are looking for Cecilia.
Episode 2: Breakin' In Is Hard to Do (Sep 29, 2026)
When the Port Wenn pharmacy is robbed, including Louisa’s critical time-sensitive medicine, Martin deduces that the culprit desperately needs his help. Meanwhile, Greg and George clash with a rival food truck owner, Sarah tries to bond with Eden, and Martin is on the receiving end of a special brand of Port Wenn affection.
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That's Amore For Me (Voices)
Scene Context: Greg and George approach Gina as her pizza truck draws their lunch customers away.
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Angelo Bello
Scene Context: Elaine films Gina's pizza promotional video despite having a urinary tract infection and is subsequently discovered.
Episode 3: Crate Expectations (Oct 6, 2026)
The citizens of Port Wenn get competitive during their annual floating crate race; Martin tries to give important medical advice when three men have positive pregnancy tests; former record-holder Sarah coaches Peter in the art of crate racing.
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The Distance
Episode 4: No Place Like Om (Oct 13, 2026)
As Martin desperately tries to leave Port Wenn to meet Eden in Boston for the weekend, he must first investigate the extremely strange behavior of three patients who have all recently visited a meditation retreat. Also, Mark is affected by the high school's graduation and Sarah's first guest in her rented spare room is none other than ex-paramour Eddie McCroy.
Episode 5: Hare Today, Gone Tomorrow (Oct 20, 2026)
When the wife of a traveling magician duo dies at the Salty Breeze, Martin must help the husband who is unable to grasp that she is gone. Also, Eden finds a letter Martin wrote to Louisa thinking it was for her and Martin gets a new medical monitor who has an instant connection to Louisa.
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Breakthrough
Emmy Meli
Scene Context: Eden Montgomery is pulled over by Sheriff Mark Mylow while singing in her vehicle.
Best Medicine Season 2 Trailer Songs
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Best Medicine Season 2 FOX Trailer Music.
Main Cast
- Josh Charles Dr. Martin Best
- Abigail Spencer Louisa Glasson
- Josh Segarra Sheriff Mark Mylow
- Annie Potts Aunt Joan
Official Trailer
Soundtrack Crossovers
Complete Soundtrack List - All Songs Played in Every Episode
| Episode | Song Title | Artist |
|---|---|---|
| E1 | Cecilia | Three Mile Hill |
| E2 | That's Amore For Me (Voices) | Daniele Benati |
| E2 | Angelo Bello | Daniele Benati |
| E3 | The Distance | CAKE |
| E5 | Breakthrough | Emmy Meli |